Blog
Latest updates and evidence-informed perspectives on bone healing.
Interpreting Positive Cutibacterium acnes Cultures in PJI
How low-grade presentation, joint context, and species context shape interpretation of positive Cutibacterium findings in PJI.
Local antimicrobial strategies in orthopaedic infection
Local antimicrobial strategies in orthopaedic infection address different operative problems, ranging from wound prophylaxis to implant-surface protection.
How Bone Grafts and Biomaterials Change Over Time After Implantation
Different bone grafts and biomaterials used to fill, support, or reconstruct bone defects follow different time paths after implantation, from rapid loss to prolonged persistence or structural retention.
Visible Graft on Follow-up Imaging: What It Can Mean
A visible graft or graft substitute on follow-up imaging can be expected, misleading, reassuring, or concerning, depending on the material and the pattern over time.
What CoNS Means in Fracture-Related Infection
CoNS is a laboratory grouping whose meaning in fracture-related infection depends on sampling pattern, species resolution, and clinical context.
Why debridement remains central in bone infection
In bone infection, outcome depends heavily on debridement because it creates the conditions in which antibiotics can work.
Sonication is no longer about sensitivity but about reproducibility
Sonication has established diagnostic value in implant-associated infection, but variation in processing limits comparability across centres.
What AI changes in infection decisions
AI can shift what becomes visible in infection care, but it also shifts exposure, justification pressure, and failure modes.
Culture-negative fracture-related infection is not primarily a laboratory failure
A proportion of fracture-related infections remain culture-negative despite appropriate sampling, reflecting biological and spatial constraints rather than laboratory error.
Why is gentamicin still used locally in orthopaedics?
Gentamicin became embedded in local antibiotic delivery because it fit PMMA cement well, and practice consolidated before comparative evidence matured.
Long-term quality-of-life impact of fracture-related infection
Fracture-related infection affects long-term function and quality of life beyond infection control and radiographic healing.
Fragmented data in bone infection outcomes
Outcome data for bone infection remain fragmented, limiting reliable estimates of survival, burden, and long-term impact.
Chronic osteomyelitis is not just prolonged inflammation
Chronic osteomyelitis shows inflammatory activity, but immune coordination differs from acute infection.